Native Human CP

• Cat.No.: CP-26450TH
• Product Overview: Full length native Human Ceruloplasmin purified from human plasma.

Specification

• Description: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.
• Tissue specificity: Expressed by the liver and secreted in plasma.
• Form: Lyophilised:Reconstitute with distilled water. Please contact Abcam for lot-specific recommended volume.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Potassium phosphate, 5mM EDTA, 20mM EACA, 100mM Potassium chloride, pH 6.8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the multicopper oxidase family.Contains 3 F5/8 type A domains.Contains 6 plastocyanin-like domains.

Gene Information

• Gene Name: CP ceruloplasmin (ferroxidase) [ Homo sapiens ]
• Official Symbol: CP
• Synonyms: CP; ceruloplasmin (ferroxidase); ceruloplasmin
• Gene ID: 1356
• mRNA Refseq: NM_000096
• Protein Refseq: NP_000087
• MIM: 117700
• Uniprot ID: P00450
• Chromosome Location: 3q23-q25
• Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metal ion SLC transporters, organism-specific biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem; Porphyrin and chlorophyll metabolism, conserved biosystem
• Function: chaperone binding; copper ion binding; ferroxidase activity; metal ion binding; oxidoreductase activity