Recombinant Human CSF2RA

• Cat.No.: CSF2RA-27475TH
• Product Overview: Recombinant full length extracellular domain of human GM-CSF Receptor alpha, fused to the Fc region of human IgG1 expressed in modified human 293 cells.

Specification

• Description: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
• Biological activity: CSF2RA-27475TH bound to protein A sepharose beads was able to pull down its ligand, GM-CSF.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical Sequence: EKSDLRTVAPASSLNVRFDSRTMNL SWDCQENTTFSKC FLTDKKNRVVEPRLSNNECSCTFRE ICLHEGVTFEVHV NTSQRGFQQKLLYPNSGREGTAAQN FSCFIYNADLMNC TWARGPTAPRDVQYFLYIRNSKRRR EIRCPYYIQDSGT HVGCHLDNLSGLTSRNYFLVNGTSR EIGIQFFDSLLDTKKIERFNPPSNV TVRCNTTHCLVRWKQPRTYQKLSYL DFQ YQLDVHRKNTQPGTENLLINVSGDL ENRYNFPSSEPRA KHSVKIRAADVRILNWSSWSEAIEF GSDDGGSSNTKVD KKVEPKSCDKTHTCPPCPAPELLGG PSVFLFPPKPKDT LMISRTPEVTCVVVDVSHEDPEVKF NWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCKVSN KAL PAPIEKTISKAKGQPREPQVYTLPP SRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNY KTTPPVLDSDGSF FLYSKLTVDKSRWQQGNVFSCSVMH EALHNHYTQKSLS LSPGK

Gene Information

• Gene Name: CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Homo sapiens ]
• Official Symbol: CSF2RA
• Synonyms: CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116
• Gene ID: 1438
• mRNA Refseq: NM_001161529
• Protein Refseq: NP_001155001
• MIM: 306250
• Uniprot ID: P15509
• Chromosome Location: Xp22.32 and Yp11.3
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem
• Function: cytokine receptor activity; receptor activity