Recombinant Human CSNK2A1

• Cat.No.: CSNK2A1-27173TH
• Product Overview: Recombinant full length Human CKII alpha; amino acids 1-391, MWt 45.1kDa.

Specification

• Description: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
• Source: E. coli
• Biological activity: Activity: >1 U/mg1 Unit is defined as 1 micromole phosphate transferred to synthetic peptide RRRDDDSDDD per min at 37 °C.CSNK2A1-27173TH is shown to be extremely salt sensitive, the highest activity is shown without salt.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 500mM Sodium chloride, 25mM Tris HCl, 1mM DTT, 0.5mM PMSF, pH 8.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: CSNK2A1 casein kinase 2, alpha 1 polypeptide [ Homo sapiens ]
• Official Symbol: CSNK2A1
• Synonyms: CSNK2A1; casein kinase 2, alpha 1 polypeptide; casein kinase II subunit alpha
• Gene ID: 1457
• mRNA Refseq: NM_001895
• Protein Refseq: NP_001886
• MIM: 115440
• Uniprot ID: P68400
• Chromosome Location: 20p13
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem
• Function: ATP binding; beta-catenin binding; nucleotide binding; protein N-terminus binding; protein binding