Recombinant Human CTCF

• Cat.No.: CTCF-26436TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-100 of Human CTCF protein with a proprietary tag; predicted mwt: 36.63 kDa.

Specification

• Description: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa
• Source: Wheat germ
• Tissue specificity: Ubiquitous. Absent in primary spermatocytes.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MEGDAVEAIVEESETFIKGKERKTY QRRREGGQEEDACHLPQNQTDGGEV VQDVNSSVQMVMMEQLDPTLLQMKT EVMEGTVAPEAEAAVDDTQIITLQV
• Sequence Similarities: Belongs to the CTCF zinc-finger protein family.Contains 11 C2H2-type zinc fingers.

Gene Information

• Gene Name: CTCF CCCTC-binding factor (zinc finger protein) [ Homo sapiens ]
• Official Symbol: CTCF
• Synonyms: CTCF; CCCTC-binding factor (zinc finger protein); transcriptional repressor CTCF; 11 zinc finger transcriptional repressor
• Gene ID: 10664
• mRNA Refseq: NM_001191022
• Protein Refseq: NP_001177951
• MIM: 604167
• Uniprot ID: P49711
• Chromosome Location: 16q21-q22.3
• Pathway: SIDS Susceptibility Pathways, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: chromatin insulator sequence binding; metal ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity