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Recombinant Human CTGF

Cat.No. : CTGF-28023TH
Product Overview : Recombinant fragment, corresponding to amino acids 253-350 of Human CTGF, a 11.2 kDa protein of 98 amino acid residues which exerts full heparin binding, cell adhesion, and mitogenic CTGF activity.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Source : E. coli
Tissue specificity : Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Biological activity : Biological Activity : Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
Form : Lyophilised
Purity : >95% by SDS-PAGE
Storage buffer : Spin down vial and reconstitute in distilled water for a concentration of 0.1 - 1.0 mg/ml.
Storage : The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Sequences of amino acids : MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA
Sequence Similarities : Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.
Gene Name : CTGF connective tissue growth factor [ Homo sapiens ]
Official Symbol : CTGF
Synonyms : CTGF; connective tissue growth factor; CCN2; IGFBP8;
Gene ID : 1490
mRNA Refseq : NM_001901
Protein Refseq : NP_001892
MIM : 121009
Uniprot ID : P29279
Chromosome Location : 6q23.2
Pathway : Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem;
Function : fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How can CTGF be measured or detected in clinical settings? 12/20/2017

CTGF levels can be measured using various techniques, including enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry.

What are the potential diagnostic applications of CTGF in medicine? 07/18/2017

CTGF levels can serve as diagnostic markers for fibrotic diseases, aiding in the early detection and monitoring of such conditions.

Are there therapeutic implications of targeting CTGF in clinical practice? 03/08/2017

Yes, targeting CTGF is being explored as a potential therapeutic strategy to mitigate fibrosis in various organs and tissues.

In which medical specialties is CTGF protein research particularly relevant? 11/18/2016

CTGF protein research is particularly relevant in specialties such as rheumatology, pulmonology, and dermatology due to its implications in fibrotic diseases.

How does CTGF contribute to fibrosis? 09/13/2016

CTGF plays a crucial role in promoting the formation of fibrous tissue by stimulating the production of extracellular matrix proteins.

Customer Reviews (3)

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Reviews
03/22/2021

    Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.

    08/06/2019

      With their assistance, I can overcome obstacles and optimize my experimental setup.

      09/23/2018

        With the CTGF protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.

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