Native Human CTSB

• Cat.No.: CTSB-26408TH
• Product Overview: Full length native Human Cathepsin B purified from liver; MWt 27.5 kDa.

Specification

• Description: The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
• Biological activity: Activity: Greater than 200 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one µmole of Z-Arg-Arg-beta-naphthylamide per minute at 40°C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Sodium acetate, 1mM EDTA, pH 5.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase C1 family.

Gene Information

• Gene Name: CTSB cathepsin B [ Homo sapiens ]
• Official Symbol: CTSB
• Synonyms: CTSB; cathepsin B
• Gene ID: 1508
• mRNA Refseq: NM_001908
• Protein Refseq: NP_001899
• MIM: 116810
• Uniprot ID: P07858
• Chromosome Location: 8p23.1
• Pathway: Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: cysteine-type endopeptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding