Native Human CTSD

• Cat.No.: CTSD-27858TH
• Product Overview: Full length native mature Cathepsin D protein purified from Human liver.

Specification

• Description: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
• Biological activity: Specific activity:541 Units/mg (prior to lyophilization).One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA.The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37oC.Substrate:
• Form: Lyophilised:Reconstitute with 28.3ul distilled water. Protein: 0.883mg/ml (prior to lyophilization).
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 2mM Sodium phosphate, pH 6.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase A1 family.

Gene Information

• Gene Name: CTSD cathepsin D [ Homo sapiens ]
• Official Symbol: CTSD
• Synonyms: CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10
• Gene ID: 1509
• mRNA Refseq: NM_001909
• Protein Refseq: NP_001900
• MIM: 116840
• Uniprot ID: P07339
• Chromosome Location: 11p15.5
• Pathway: Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: aspartic-type endopeptidase activity; peptidase activity