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Native Human CTSD

Cat.No.: CTSD-27858TH
Product Overview: Full length native mature Cathepsin D protein purified from Human liver.
Description: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Biological activity: Specific activity:541 Units/mg (prior to lyophilization).One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA.The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37oC.Substrate:
Form: Lyophilised:Reconstitute with 28.3ul distilled water. Protein: 0.883mg/ml (prior to lyophilization).
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 2mM Sodium phosphate, pH 6.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the peptidase A1 family.
Gene Name: CTSD cathepsin D [ Homo sapiens ]
Official Symbol: CTSD
Synonyms: CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10;
Gene ID: 1509
mRNA Refseq: NM_001909
Protein Refseq: NP_001900
MIM: 116840
Uniprot ID: P07339
Chromosome Location: 11p15.5
Pathway: Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem;
Function: aspartic-type endopeptidase activity; peptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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