||Full length native mature Cathepsin D protein purified from Human liver.
||This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
||Specific activity:541 Units/mg (prior to lyophilization).One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA.The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37oC.Substrate:
||Lyophilised:Reconstitute with 28.3ul distilled water. Protein: 0.883mg/ml (prior to lyophilization).
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 2mM Sodium phosphate, pH 6.5
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
||Belongs to the peptidase A1 family.