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Recombinant Human CXCR3

Cat.No. : CXCR3-26725TH
Product Overview : Recombinant fragment corresponding to amino acids 1-53 of Human CXCR3 with a proprietary tag; Predicted MWt 31.46.
  • Specification
  • Gene Information
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Description : This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Protein length : 53 amino acids
Molecular Weight : 31.460kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
Biological activity : useful for Antibody Production and Protein Array
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MVLEVSDHQVLNDAEVAALLENFSS SYDYGENESDSCCTSPPCPQDFSLN FDR
Sequence Similarities : Belongs to the G-protein coupled receptor 1 family.
Gene Name : CXCR3 chemokine (C-X-C motif) receptor 3 [ Homo sapiens ]
Official Symbol : CXCR3
Synonyms : CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR;
Gene ID : 2833
mRNA Refseq : NM_001142797
Protein Refseq : NP_001136269
MIM : 300574
Uniprot ID : P49682
Chromosome Location : Xq13
Pathway : CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
Function : C-X-C chemokine receptor activity; G-protein coupled receptor activity; chemokine binding; chemokine receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of chemokines and their receptors, particularly CXCR3, in immune cell processes? 10/18/2020

The primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.

How many variant isoforms of CXCR3 exist, and what are their names? 03/20/2020

There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.

Which ligands are associated with the chemokine receptor CXCR3, and what are their roles during interferon-induced inflammatory responses? 01/18/2019

The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.

What aspect of the inflammatory process in human skin involving CXCR3 chemokines and isoforms requires further investigation, according to the information provided? 12/18/2018

The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.

What is the focus of the review regarding CXCR3, its ligands, and their role in skin during inflammation and carcinogenesis? 05/16/2018

The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.

In the context of skin cancers, what dual role can the CXCR3 receptor play, and how does its expression on different cell types contribute to cancer outcomes? 01/14/2018

In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.

What drives the expression of CXCL9, CXCL10, and CXCL11, and what is their function in recruiting CXCR3+ T cells during skin inflammation? 11/27/2016

The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.

Customer Reviews (3)

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Reviews
12/11/2019

    The continuous innovation and improvements made by the manufacturer indicated a promising future for the product.

    07/30/2019

      Inclusion of the product consistently led to a significant upregulation of target protein expression levels.

      12/19/2016

        We were excited about the product's role in driving future discoveries in our field of study.

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