Recombinant Human CYP1A1

• Cat.No.: CYP1A1-27558TH
• Product Overview: Recombinant full length Human Cytochrome P450 1A1 with N terminal proprietary tag; Predicted MWt 82.06 kDa.

Specification

• Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
• Protein length: 512 amino acids
• Molecular Weight: 82.060kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Lung, lymphocytes and placenta.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNP PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGS TPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICA ICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFD TVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFY IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
• Sequence Similarities: Belongs to the cytochrome P450 family.

Gene Information

• Gene Name: CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [ Homo sapiens ]
• Official Symbol: CYP1A1
• Synonyms: CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1; cytochrome P450 1A1; CP11; P1 450; P450 C; P450DX
• Gene ID: 1543
• mRNA Refseq: NM_000499
• Protein Refseq: NP_000490
• MIM: 108330
• Uniprot ID: P04798
• Chromosome Location: 15q24.1
• Pathway: Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: aromatase activity; demethylase activity; electron carrier activity; enzyme binding; flavonoid 3-monooxygenase activity