Recombinant Human DDR2 Protein (22-399aa), C-His tagged

• Cat.No.: DDR2-28310TH
• Product Overview: Recombinant human DDR2 (22-399aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
• Source: Baculovirus
• Species: Human
• Tag: C-His
• Form: Liquid
• Molecular Mass: 43.7 kDa (386aa)
• Protein Length: 22-399aa
• AA Sequence: KAQVNPAICRYPLGMSGGQIPDEDI TASSQWSESTAAKYGRLDSEEGDGA WCPEIPVEPDDLKEFLQIDLHTLHF ITLVGTQGRHAGGHGIEFAPMYKIN YSRDGTRWISWRNRHGKQVLDGNSN PYDIFLKDLEPPIVARFVRFIPVTD HSMNVCMRVELYGCVWLDGLVSYNA PAGQQFVLPGGSIIYLNDSVYDGAV GYSMTEGLGQLTDGVSGLDDFTQTH EYHVWPGYDYVGWRNESATNGYIEI MFEFDRIRNFTTMKVHCNNMFAKGV KIFKEVQCYFRSEASEWEPNAISFP LVLDDVNPSARFVTVPLHHRMASAI KCQYHFADTWMMFSEITFQSDAAMY NNSEALPTSPMAPTTYDPMLKVDDS NTR< LEHHHHHH>
• Endotoxin: < 1 EU/μg of protein (determined by LAL method)
• Purity: > 90% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL (determined by absorbance at 280nm)
• Storage Buffer: Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Gene Information

• Gene Name: DDR2 discoidin domain receptor tyrosine kinase 2 [ Homo sapiens (human) ]
• Official Symbol: DDR2
• Synonyms: DDR2; discoidin domain receptor tyrosine kinase 2; discoidin domain receptor family, member 2, NTRKR3, TYRO10; discoidin domain-containing receptor 2; TKT; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2; MIG20a; NTRKR3; TYRO10
• Gene ID: 4921
• mRNA Refseq: NM_001014796
• Protein Refseq: NP_001014796
• MIM: 191311
• UniProt ID: Q16832