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Recombinant Human DECR1, His-tagged

Cat.No. : DECR1-26259TH
Product Overview : Recombinant full length Human DECR1 with N terminal His tag; 322 amino acids with tag, MWt 34.4 kDa.
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  • Gene Information
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Description : This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.
Protein length : 301 amino acids
Conjugation : HIS
Molecular Weight : 34.400kDa inclusive of tags
Source : E. coli
Tissue specificity : Heart = liver = pancreas >kidney >>skeletal muscle = lung.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHM NTEALQSKFFSPLQKAMLPPNSFQG KVAFITGGGTGLGKGMTTLLSSLGA QCVIASRKMDVLKATAEQISSQTGN KVHAIQCDVRDPDMVQNTVSELIKV AGHPNIVINNAAGNFISPTERLSPN AWKTITDIVLNGTAFVTLEIGKQLI KAQKGAAFLSITTIYAETGSGFVVP SASAKAGVEAMSKSLAAEWGKYGMR FNVIQPGPIKTKGAFSRLDPTGTFE KEMIGRIPCGRLGTVEELANLAAFL CSDYASWINGAVIKFDGGEEVLISG EFNDLRKVTKEQWDTIEELIRKTKG S
Sequence Similarities : Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Gene Name : DECR1 2,4-dienoyl CoA reductase 1, mitochondrial [ Homo sapiens ]
Official Symbol : DECR1
Synonyms : DECR1; 2,4-dienoyl CoA reductase 1, mitochondrial; DECR; 2,4-dienoyl-CoA reductase, mitochondrial; SDR18C1; short chain dehydrogenase/reductase family 18C; member 1;
Gene ID : 1666
mRNA Refseq : NM_001359
Protein Refseq : NP_001350
Uniprot ID : Q16698
Chromosome Location : 8q21.3
Pathway : Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Mitochondrial Fatty Acid Beta-Oxidation, organism-specific biosystem;
Function : 2,4-dienoyl-CoA reductase (NADPH) activity; 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding; nucleotide binding; oxidoreductase activity, acting on NADH or NADPH;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does DECR1 interact with other enzymes in the fatty acid oxidation pathway? 06/23/2023

DECR1 works alongside other enzymes in β-oxidation, ensuring effective fatty acid degradation.

What role does DECR1 play in energy production and mitochondrial function? 06/08/2023

DECR1 plays a role in energy production by aiding in the efficient processing of fatty acids in mitochondria.

How do genetic variations in the DECR1 gene affect metabolic processes and disease susceptibility? 02/08/2022

Mutations in DECR1 can impact fatty acid metabolism, potentially leading to metabolic disorders.

How does DECR1 contribute to the breakdown of unsaturated fatty acids? 02/18/2021

It specifically catalyzes the reduction of double bonds in unsaturated fatty acids, facilitating their breakdown.

What is the impact of altered DECR1 activity on metabolic disorders such as diabetes or obesity? 10/02/2018

Altered DECR1 activity can affect energy balance and fat metabolism, influencing conditions like diabetes and obesity.

What potential therapeutic applications could arise from targeting DECR1 in metabolic diseases? 03/26/2018

Targeting DECR1 could offer new treatment avenues for managing metabolic conditions like obesity and diabetes.

What is the primary function of DECR1 in fatty acid metabolism? 05/04/2017

DECR1, or 2,4-dienoyl-CoA reductase 1, is key in the metabolism of unsaturated fatty acids, particularly in β-oxidation.

Customer Reviews (3)

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Reviews
10/29/2022

    Invaluable support. Crucial for protein experiments.

    07/12/2022

      Key to credibility. Enhances research credibility.

      10/12/2019

        Swift and accurate. An asset to our research.

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