Recombinant Human DEFA1, His-tagged

• Cat.No.: DEFA1-26186TH
• Product Overview: Recombinant full length protein (Human).This (mature) protein is a 3.4 kDa protein containing 30 amino acid residues.

Specification

• Description: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:This protein should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other buffer solutions. The reconstituted protein should be stored in working aliquots at -20°C.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneBuffer: NoneEndotoxin level:
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequence Similarities: Belongs to the alpha-defensin family.

Gene Information

• Gene Name: DEFA1 defensin, alpha 1 [ Homo sapiens ]
• Official Symbol: DEFA1
• Synonyms: DEFA1; defensin, alpha 1; DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS; neutrophil defensin 1; HNP 1
• Gene ID: 1667
• mRNA Refseq: NM_004084
• Protein Refseq: NP_004075
• MIM: 125220
• Uniprot ID: P59665
• Chromosome Location: 8p23.1
• Pathway: Cellular roles of Anthrax toxin, organism-specific biosystem