Recombinant Human DEFA1

• Cat.No.: DEFA1-26678TH
• Product Overview: Highly pure (>98%) recombinant human alpha Defensin 1.

Specification

• Description: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
• Source: E. coli
• Form: Lyophilised
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues:ACYCRIPACIAGERRYGYCIYQGRL WAFCC
• Sequence Similarities: Belongs to the alpha-defensin family.

Gene Information

• Gene Name: DEFA1 defensin, alpha 1 [ Homo sapiens ]
• Official Symbol: DEFA1
• Synonyms: DEFA1; defensin, alpha 1; DEF1, DEFA2, defensin, alpha 1, myeloid related sequence , defensin, alpha 2 , MRS; neutrophil defensin 1; HNP 1
• Gene ID: 1667
• mRNA Refseq: NM_004084
• Protein Refseq: NP_004075
• MIM: 125220
• Uniprot ID: P59665
• Chromosome Location: 8p23.1
• Pathway: Cellular roles of Anthrax toxin, organism-specific biosystem