Recombinant Human DLL4
Cat.No. : | DLL4-26674TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 27-524 of Human DLL4 expressed in 293 cells; 498 amino acids, 54.0 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. |
Tissue specificity : | Expressed in vascular endothelium. |
Biological activity : | Biological Activity :DLL4-26674TH, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells. |
Form : | Lyophilised:Reconstituted DLL4-26674TH is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
Purity : | >95% by SDS-PAGE |
Storage : | Store at -20°C. Stable for 12 months at -20°C |
Sequences of amino acids : | SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP |
Sequence Similarities : | Contains 1 DSL domain.Contains 8 EGF-like domains. |
Gene Name : | DLL4 delta-like 4 (Drosophila) [ Homo sapiens ] |
Official Symbol : | DLL4 |
Synonyms : | DLL4; delta-like 4 (Drosophila); delta like 4 homolog (Drosophila); delta-like protein 4; |
Gene ID : | 54567 |
mRNA Refseq : | NM_019074 |
Protein Refseq : | NP_061947 |
MIM : | 605185 |
Uniprot ID : | Q9NR61 |
Chromosome Location : | 15q14 |
Pathway : | Delta-Notch Signaling Pathway, organism-specific biosystem; Notch receptor binds with a ligand, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; |
Function : | Notch binding; calcium ion binding; |
Products Types
◆ Recombinant Protein | ||
DLL4-2687H | Recombinant Human DLL4 Protein, GST-tagged | +Inquiry |
DLL4-001H | Recombinant Human DLL4 Protein, His-tagged | +Inquiry |
DLL4-1349H | Recombinant Human DLL4 Protein, His&GST-tagged | +Inquiry |
DLL4-202H | Recombinant Human DLL4 Protein, Fc-tagged | +Inquiry |
DLL4-1021R | Active Recombinant Rhesus DLL4 Protein (Met1-Pro528), His-tagged | +Inquiry |
◆ Lysates | ||
DLL4-2495MCL | Recombinant Mouse DLL4 cell lysate | +Inquiry |
DLL4-2507HCL | Recombinant Human DLL4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDLL4 is implicated in the regulation of vascular inflammation and plaque formation, making it a potential target for atherosclerosis treatments.
DLL4 has been linked to Alzheimer's disease as it can influence amyloid-beta accumulation and the activation of microglia in the brain.
DLL4 levels can serve as a potential biomarker in some diseases, such as certain cancers, where it may indicate disease progression.
Challenges include potential side effects, the need for personalized treatment approaches, and the complexity of the Notch signaling pathway.
DLL4 can modulate tissue regeneration by influencing stem cell behavior and promoting tissue repair processes.
Customer Reviews (3)
Write a reviewThey ensure a consistent and reliable supply of DLL4 protein, minimizing any potential disruptions in my experimental workflow.
the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.
This collaborative approach empowers me to integrate cutting-edge knowledge, explore innovative techniques, and expand the impact of my research.
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