Recombinant Human DNM2, His-tagged
Cat.No. : | DNM2-26990TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 529-824 of Human Dynamin 2 with N terminal His tag. MWt 34kDa; |
- Specification
- Gene Information
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Description : | Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Lyophilised:Reconstitution with 104 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | (Amino acid sequence (Sequence determined by 5 Sequencing))LMKGGSKEYWFVLTAESLSWYKDEE E KEKKYMLPLDNLKIRDVEKGFMSNK HVFAIFNTEQRNV YKDLRQIELACDSQEDVDSWKASFL RAGVYPEKDQAENEDGAQENTFSMD PQLERQVETIRNLVDSYVAIINKSI RDL MPKTIMHLMINNTKAFIHHELLAYL YSSADQSSLMEES ADQAQRRDDMLRMYHALKEALNIIG DISTSTVSTPVPP PVDDTWLQSASSHSPTPQRRPVSSI HPPGRPPAVRGPTPG PPLIPVPVGAAASFSAPPIPSRPGP QSVFANSDLFPAP |
Gene Name : | DNM2 dynamin 2 [ Homo sapiens ] |
Official Symbol : | DNM2 |
Synonyms : | DNM2; dynamin 2; dynamin-2; CMTDI1; CMTDIB; cytoskeletal protein; DI CMTB; DYN2; dynamin II; DYNII; |
Gene ID : | 1785 |
mRNA Refseq : | NM_001005360 |
Protein Refseq : | NP_001005360 |
MIM : | 602378 |
Uniprot ID : | P50570 |
Chromosome Location : | 19p |
Pathway : | Arf6 trafficking events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Clathrin derived vesicle budding, organism-specific biosystem; |
Function : | GTP binding; GTPase activity; GTPase activity; enzyme binding; hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
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Dnm2-2619M | Recombinant Mouse Dnm2 Protein, Myc/DDK-tagged | +Inquiry |
DNM2-1583R | Recombinant Rat DNM2 Protein, His (Fc)-Avi-tagged | +Inquiry |
DNM2-1132R | Recombinant Rhesus Macaque DNM2 Protein, His (Fc)-Avi-tagged | +Inquiry |
DNM2-1307R | Recombinant Rhesus monkey DNM2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DNM2-6857HCL | Recombinant Human DNM2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionDNM2 interacts with β-actin.
DNM2 is closely associated with the study of chronic heart failure and chronic progressive extraocular muscle paralysis in the elderly.
DNM2 gene is widely expressed in various mammalian tissues.
DNM1 and DNM3 are all homologs of DNM2.
DNM2 is involved in the regulation of Golgi reticular system transport, mitochondrial fusion, cytoplasmic division and synaptic vesicle endocytosis.
N-terminal GTPase structural domain, intermediate domain, PH structural domain, GTPase effector structural domain, and C-terminal proline- and arginine-rich domain.
Customer Reviews (3)
Write a reviewDNM2 proteins purchased are as advertised and the quality of the product is guaranteed.
Excellent after-sales service, solving many experimental problems.
The technician gave me a thorough introduction to the DNM2 protein so that I could understand its biochemical properties.
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