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Recombinant Human DOT1L

Cat.No. : DOT1L-27742TH
Product Overview : Recombinant fragment, corresponding to amino acids 2-416 of Human KMT4 / Dot1L with N terminal proprietary tag, 73 kDa.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.
Source : E. coli
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Gene Name : DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ]
Official Symbol : DOT1L
Synonyms : DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4;
Gene ID : 84444
mRNA Refseq : NM_032482
Protein Refseq : NP_115871
MIM : 607375
Uniprot ID : Q8TEK3
Chromosome Location : 19p13.3
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which DOT1L modulates transcriptional regulation in various cell types? 06/04/2021

DOT1L modulates transcriptional regulation, affecting gene expression patterns in different cell types.

How do alterations in DOT1L expression or activity affect cellular aging and the development of age-related diseases? 04/28/2021

Variations in DOT1L activity impact cellular aging and may contribute to age-related diseases.

How does DOT1L influence embryonic development and stem cell differentiation? 10/10/2020

DOT1L influences embryonic development and stem cell differentiation through epigenetic regulation.

How does DOT1L contribute to the pathogenesis of leukemia, particularly MLL-rearranged leukemia? 06/16/2019

DOT1L contributes to leukemia development, especially in MLL-rearranged cases, by altering gene expression.

How does DOT1L (Disruptor of Telomeric Silencing 1-Like) regulate histone methylation and gene expression? 03/13/2019

DOT1L regulates gene expression by methylating histone H3, affecting chromatin and gene activity.

What role does DOT1L play in the development and maintenance of chromatin structure? 11/06/2018

DOT1L plays a crucial role in chromatin structure and stability, influencing genomic integrity.

What is the impact of DOT1L inhibition on epigenetic therapies for cancer treatment? 02/08/2018

Inhibiting DOT1L shows promise in epigenetic cancer therapies by modifying disease-related gene expression.

Customer Reviews (3)

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Reviews
11/04/2022

    Efficient protein purification, consistently delivers high yield and purity.

    11/21/2020

      Precise protein quantification, ensures data precision in our experiments.

      02/11/2018

        Dependable peptide synthesis, accelerates our peptide-focused projects effectively.

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