Recombinant Human DOT1L
Cat.No. : | DOT1L-27742TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 2-416 of Human KMT4 / Dot1L with N terminal proprietary tag, 73 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 7.5 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Gene Name : | DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ] |
Official Symbol : | DOT1L |
Synonyms : | DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4; |
Gene ID : | 84444 |
mRNA Refseq : | NM_032482 |
Protein Refseq : | NP_115871 |
MIM : | 607375 |
Uniprot ID : | Q8TEK3 |
Chromosome Location : | 19p13.3 |
Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem; |
Function : | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
DOT1L-2821H | Recombinant Human DOT1L Protein, GST-tagged | +Inquiry |
DOT1L-130H | Recombinant Human DOT1L Protein, GST-tagged | +Inquiry |
DOT1L-006H | Recombinant Human DOT1L Protein, GST-tagged | +Inquiry |
DOT1L21203H | Recombinant Human Dot1L (1-351) Protein | +Inquiry |
DOT1L-2979H | Recombinant Human DOT1L protein, His-tagged | +Inquiry |
◆ Lysates | ||
DOT1L-6841HCL | Recombinant Human DOT1L 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionDOT1L modulates transcriptional regulation, affecting gene expression patterns in different cell types.
Variations in DOT1L activity impact cellular aging and may contribute to age-related diseases.
DOT1L influences embryonic development and stem cell differentiation through epigenetic regulation.
DOT1L contributes to leukemia development, especially in MLL-rearranged cases, by altering gene expression.
DOT1L regulates gene expression by methylating histone H3, affecting chromatin and gene activity.
DOT1L plays a crucial role in chromatin structure and stability, influencing genomic integrity.
Inhibiting DOT1L shows promise in epigenetic cancer therapies by modifying disease-related gene expression.
Customer Reviews (3)
Write a reviewEfficient protein purification, consistently delivers high yield and purity.
Precise protein quantification, ensures data precision in our experiments.
Dependable peptide synthesis, accelerates our peptide-focused projects effectively.
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