Recombinant Human Microtubule-Associated Protein Tau

• Cat.No.: MAPT-1572H
• Product Overview: Recombinant human full-length tag-free Tau-352 Protein was expressed inE. coli.MW=49kDa.

Specification

• Cat. No.: MAPT-1572H
• Description: Tau-352 or Tau-A is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer"s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system.
• Source: E. coli.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAPT microtubule-associated protein tau [ Homo sapiens ]
• Synonyms: MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau
• Gene ID: 4137
• mRNA Refseq: NM_001123066
• Protein Refseq: NP_001116538
• UniProt ID: P10636
• Chromosome Location: 17q21.1
• MIM: 157140
• Pathway: Alzheimer"s disease; MAPK signaling pathway; Apoptosis
• Function: axon; cell projection; cytoplasm; cytoskeleton; growth cone; microtubule; microtubule associated complex; plasma membrane; tubulin complex