Recombinant Human Activin A Receptor, Type I
Cat.No. : | ACVR1-1583H |
- Specification
- Gene Information
- Related Products
Cat. No. : | ACVR1-1583H |
Description : | The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones include activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors: ACVR1, ACVR1B, and ACVR1C. Activin isoforms and other members of the TGF-β superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human Activin RIA is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40-45 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | ACVR1 activin A receptor, type I [ Homo sapiens ] |
Synonyms : | ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30 |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Chromosome Location : | 2q23-q24 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function : | ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding |
Products Types
◆ Recombinant Protein | ||
ACVR1-274H | Recombinant Human ACVR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVR1-0159H | Recombinant Human ACVR1 Protein (T172-C509), His tagged | +Inquiry |
ACVR1-1022H | Recombinant Human ACVR1 Protein, MYC/DDK-tagged | +Inquiry |
ACVR1-0158H | Recombinant Human ACVR1 Protein (T172-C509), Tag Free | +Inquiry |
Acvr1-775M | Active Recombinant Mouse Acvr1 protein(Met1-Glu123), His&hFc-tagged | +Inquiry |
◆ Lysates | ||
ACVR1-3097HCL | Recombinant Human ACVR1 cell lysate | +Inquiry |
ACVR1-1305RCL | Recombinant Rat ACVR1 cell lysate | +Inquiry |
ACVR1-1232CCL | Recombinant Cynomolgus ACVR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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