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Recombinant Mouse Activin A Receptor, Type II-like 1, Fc-tagged

Cat.No. : Acvrl1-498M
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Cat. No. : Acvrl1-498M
Product overview : Recombinant Mouse Acvrl1 encoding the signal peptide from human CD33 joined with amino acid residues 23 - 119 of the extracellular domain of mouse Activin Receptor-Like Kinase 1was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells.
Description : Activin A receptor type II-like 1, also known as ACVRL1, is a human gene. ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as "activin receptor-like kinase 1", or "ALK1". This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 suggesting a critical role for ALK-1 in the control of blood vessel development or repair. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular regions.
Molecular Weight : The predicted molecular weight of Recombinant Mouse ALK-1 is Mr 37.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 50-55 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : Measured by its ability to inhibit recombinant Human BMP-9 induced alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is 20 - 80 ng/ml in the presence of 2 ng/ml of recombinant Human BMP-9.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Acvrl1 activin A receptor, type II-like 1 [ Mus musculus ]
Synonyms : Acvrl1; activin A receptor, type II-like 1; Alk1; Acvrlk1; AI115505; AI427544; activin A receptor type II-like 1; activin receptor-like kinase-1; EC 2.7.11.30; Alk-1
Gene ID : 11482
mRNA Refseq : NM_009612
Protein Refseq : NP_033742
UniProt ID : Q61288
Chromosome Location : 15 F3
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; activin receptor activity, type I; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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