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Recombinant Human EIF2AK2

Cat.No. : EIF2AK2-31020TH
Product Overview : Recombinant fragment, corresponding to amino acids 252-551 of Human PKR with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 64kDa.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
Biological activity : The Specific activity of EIF2AK2-31020TH was determined to be 53-59 nmol/min/mg dependent on lot.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.Contains 2 DRBM (double-stranded RNA-binding) domains.Contains 1 protein kinase domain.
Gene Name : EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Homo sapiens ]
Official Symbol : EIF2AK2
Synonyms : EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PRKR, protein kinase, interferon inducible double stranded RNA dependent; interferon-induced, double-stranded RNA-activated protein kinase; EIF2AK1; PKR;
Gene ID : 5610
mRNA Refseq : NM_001135651
Protein Refseq : NP_001129123
MIM : 176871
Uniprot ID : P19525
Chromosome Location : 2p22-p21
Pathway : Ceramide signaling pathway, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem;
Function : ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does EIF2AK2 relate to apoptosis? 04/17/2022

EIF2AK2 can be involved in the regulation of apoptosis by triggering the apoptotic process by inducing eIF2α phosphorylation.

Are there other coding variants in the EIF2AK gene? 02/24/2021

Yes, in addition to the primary EIF2AK gene, there are other coding variants that may have different functions and expression patterns.

How is EIF2AK2 related to the development of tumors? 10/18/2020

Studies have shown that EIF2AK2 abnormal expression levels in some tumors may be related to the occurrence and progression of tumors.

What are the possible causes of abnormal EIF2AK2 expression levels? 09/08/2020

Abnormal EIF2AK2 expression levels may be due to genetic mutations, chromosomal abnormalities, environmental factors, etc.

How does EIF2AK2 have to do with viral infection? 05/05/2020

Studies have shown that EIF2AK2 can participate in the regulation of antiviral immune responses and affect the course of viral infections.

What are the applications of EIF2AK2 in drug discovery? 12/28/2019

EIF2AK2 can be used as a target for the development of new drugs, especially in the areas of neurodegenerative diseases and autoimmune diseases.

Customer Reviews (3)

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Reviews
03/05/2022

    EIF2AK2 has a low immunogenicity and does not cause an abnormal immune response.

    01/02/2022

      Remarkable progress has been made in the application of EIF2AK2 in related fields.

      06/14/2021

        The activity of EIF2AK2 is similar to that of natural proteins and is able to perform its intended biological function.

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