Catalog # or name ...
Bcl-2-like protein 11 is a protein that in humans is encoded
by the BCL2L11 gene. The protein encoded by this gene
belongs to the BCL-2 protein family. BCL-2 family members
form hetero- or homodimers and act as anti- or pro-apoptotic
regulators that are involved in a wide variety of cellular
activities. The protein encoded by this gene contains a
Bcl-2 homology domain 3 (BH3). It has been shown to interact
with other members of the BCL-2 protein family, including
BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic
activator. The expression of this gene can be induced by
nerve growth factor (NGF), as well as by the forkhead
transcription factor FKHR-L1, which suggests a role of this
gene in neuronal and lymphocyte apoptosis. Transgenic
studies of the mouse counterpart suggested that this gene
functions as an essential initiator of apoptosis in
thymocyte-negative selection. Several alternatively spliced
transcript variants of this gene have been identified.
State Of Matter
>95% by SDS Page and HPLC.
The predicted molecular weight of Recombinant Human BIM is
Mr 22 kDa.
BCL2L11 BCL2-like 11 (apoptosis facilitator) [ Homo sapiens
BCL2-like 11 (apoptosis facilitator); BAM; BIM; BOD; BimL;
BimEL; BIM-beta6; BIM-beta7; BIM-alpha6; BCL2L11; BCL2-like
11; OTTHUMP00000197013; bcl-2 interacting protein Bim;
bcl-2-related ovarian death agonist; bcl-2 interacting
mediator of cell death; Bcl2-L-11; Bcl2-interacting mediator
of cell death
Apoptosis; Signalling by NGF
microtubule binding; protein binding
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