Recombinant Human ERBB2

• Cat.No.: ERBB2-26845TH
• Product Overview: Recombinant fragment, corresponding to 1 initial methionine + amino acids 23 - 340 of Human ErbB 2 + 79 amino acids of intron 8.

Specification

• Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
• Source: E. coli
• Tissue specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.05M Sodium acetate, pH 4
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: M-TQVCTGTDM KLRLPASPET HLDMLRHLYQ GCQVVQGNLELTYLPTNASL SFLQDIQEVQ GYVLIAHNQV RQVPLQRLRIVRGTQLFEDN YALAVLDNGD PLNNTTPVTG ASPGGLRELQLRSLTEILKG GVLIQRNPQL CYQDTILWKD IFHKNNQLALTLIDTNRSRA CHPCSPMCKG SRCWGESSED CQSLTRTVCAGGCARCKGPL PTDCCHEQCA AGCTGPKHSD CLACLHFNHSGICELHCPAL VTYNTDTFES MPNPEGRYTF GASCVTACPYNYLSTDVGSC TLVCPLHNQE VTAEDGTQRC EKCSKPCARGTHSLPPRPAA VPVPLRMQPG PAHPVLSFLR PSWDLVSAFYSLPLAPLSPT SVPISPVSVG RGPDPDAHVA VDLSRYEG
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ]
• Official Symbol: ERBB2
• Synonyms: ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-p
• Gene ID: 2064
• mRNA Refseq: NM_001005862
• Protein Refseq: NP_001005862
• MIM: 164870
• Uniprot ID: P04626
• Chromosome Location: 17q11.2-q12
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Bladder cancer, organism-specific biosystem
• Function: ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; RNA polymerase I core binding; epidermal growth factor-activated receptor activity