Recombinant Human F7

• Cat.No.: F7-28711TH
• Product Overview: Human Recombinant Full length Factor VIIa produced in BHK is a glycosylated polypeptide two-chain dimer consisting of 406 amino acids with a molecular weight of 50kD.

Specification

• Description: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
• Biological activity: Biological Activity: The potency per mg was tested and found to be 50,000Units/mg.
• Form: Lyophilised:It is recommended to reconstitute the lyophilized Factor-VIIa in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mg/ml Mannitol, 4.86mg/ml Sodium chloride dihydrate, 2.45mg/ml Calcium chloride, 116μg/ml Tween 80
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ]
• Official Symbol: F7
• Synonyms: F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein
• Gene ID: 2155
• mRNA Refseq: NM_000131
• Protein Refseq: NP_000122
• MIM: 613878
• Uniprot ID: P08709
• Chromosome Location: 13q34
• Pathway: BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem
• Function: calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity