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Recombinant Human FBN1

Cat.No. : FBN1-28892TH
Product Overview : Recombinant fragment corresponding to amino acids 2772-2871 of Human Fibrillin 1 with an N terminal proprietary tag; Predicted MWt 36.63 kDa.
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  • Gene Information
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Description : This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : SNKVRILELLPALTTLTNHNRYLIE SGNEDGFFKINQKEGISYLHFTKKK PVAGTYSLQISSTPLYKKKELNQLE DKYDKDYLSGELGDNLKMKIQVLLH
Sequence Similarities : Belongs to the fibrillin family.Contains 47 EGF-like domains.Contains 9 TB (TGF-beta binding) domains.
Gene Name : FBN1 fibrillin 1 [ Homo sapiens ]
Official Symbol : FBN1
Synonyms : FBN1; fibrillin 1; FBN, fibrillin 1 (Marfan syndrome) , MFS1, WMS; fibrillin-1; Marfan syndrome; MASS; OCTD; SGS;
Gene ID : 2200
mRNA Refseq : NM_000138
Protein Refseq : NP_000129
MIM : 134797
Uniprot ID : P35555
Chromosome Location : 15q21.1
Pathway : Integrin cell surface interactions, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function : calcium ion binding; extracellular matrix structural constituent; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What potential therapeutic applications arise from targeting FBN1 in connective tissue disorders? 06/23/2023

Targeting FBN1 offers potential for treating connective tissue disorders by restoring matrix integrity and function.

How do genetic variations in FBN1 affect connective tissue disorders? 06/08/2023

Genetic mutations in FBN1 can lead to various connective tissue disorders, affecting tissue strength and flexibility.

What is the impact of altered FBN1 activity on cardiovascular health? 02/08/2022

Altered FBN1 activity is associated with cardiovascular conditions due to its role in maintaining blood vessel structure.

What role does FBN1 play in connective tissue development? 02/18/2021

FBN1 plays a critical role in the development of connective tissues, including tendons, ligaments, and blood vessels.

What is the primary role of FBN1 in extracellular matrix formation? 12/29/2019

FBN1, or Fibrillin-1, is essential for the formation of the extracellular matrix, providing structural support to tissues.

How does FBN1 interact with other extracellular matrix proteins? 10/02/2018

FBN1 interacts with other extracellular matrix proteins, such as elastin, in building and maintaining tissue architecture.

How does FBN1 contribute to tissue elasticity and structural integrity? 05/04/2017

It contributes to tissue elasticity and integrity by forming microfibrils that reinforce the matrix.

Customer Reviews (3)

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Reviews
10/12/2022

    Excellent in cell culture functionality

    05/03/2020

      Exceptional specificity in immunohistochemistry

      04/14/2020

        Highly stable and reliable in assays

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