| Description : |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Protein length : |
210 amino acids |
| Molecular Weight : |
49.210kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Specifically expressed in cardiac and skeletal muscle. |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MNILEKVVLKVLEDQQNIRLIRELL QTLYTSLCTLVQRVGKSVLVGNINM WVYRMETILHWQQQLNNIQITRPAF KGLTFTDLPLCLQLNIMQRLSDGRD LVSLGQAAPDLHVLSEDRLLWKKLC QYHFSERQIRKRLILSGKGQLDWKK MYFKLVRCYPRKEQYGDTLQLRKHC HILSWKGTDHPCTANNPESCSVSLS PQDFINLFKF |
| Sequence Similarities : |
Contains 1 F-box domain. |
