Native Human FGF1

• Cat.No.: FGF1-26203TH
• Product Overview: Human FGF1.

Specification

• Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
• Source: E. coli
• Form: Lyophilised
• Storage buffer: Preservative: NoneConstituents: 5mM Sodium phosphate, 100mM Sodium chloride, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: Recombinant Human FGF1 is a 15.8 kDa protein containing 140 amino acid residues:MFNLPPGNYKKPKLLYCSNGGHFLR ILPDGTVDGTRDRSDQHIQLQLSAE SVGEVYIKSTETGQYLA MDT DGLLYGSQTPNEECLFLERLEENHY NTYISKKHAEK NWFVGLKKNGSCKRGPRTHYGQKAI LFLPLPVSSD
• Sequence Similarities: Belongs to the heparin-binding growth factors family.

Gene Information

• Gene Name: FGF1 fibroblast growth factor 1 (acidic) [ Homo sapiens ]
• Official Symbol: FGF1
• Synonyms: FGF1; fibroblast growth factor 1 (acidic); FGFA; heparin-binding growth factor 1; AFGF; ECGF; ECGF beta; ECGFA; ECGFB; endothelial cell growth factor; alpha; beta; FGF alpha; GLIO703; HBGF1; heparin binding growth factor 1
• Gene ID: 2246
• mRNA Refseq: NM_000800
• Protein Refseq: NP_000791
• MIM: 131220
• Uniprot ID: P05230
• Chromosome Location: 5q31.3-q33.2
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem
• Function: S100 alpha binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding