Recombinant Mouse Cdh3 protein, Fc-tagged

• Cat.No.: Cdh3-1673M
• Product Overview: Recombinant Mouse Cdh3 (Glu100-Gly647) fussed with Fc region of human IgG1 tag at N-terminal was expressed in HEK293 cells.

Specification

• Description: This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants.
• Source: HEK293 cells
• Species: Mouse
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Molecular Mass: The predicted molecular mass is 86 kDa, and the apparent molecular mass is approximately 110 kDa in SDS-PAGE under reducing conditions.
• Protein length: Glu100-Gly647
• Endotoxin: < 5 EU per mg of the protein as determined by the LAL method.
• Purity: > 95%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade to-70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.1 ug/ul. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: Cdh3 cadherin 3 [ Mus musculus ]
• Official Symbol: Cdh3
• Synonyms: CDH3; cadherin 3; cadherin-3; placental cadherin; Cadp; Pcad; AI385538; P-cadherin
• Gene ID: 12560
• mRNA Refseq: NM_001037809
• Protein Refseq: NP_001032898
• UniProt ID: P10287
• Chromosome Location: 8 D3; 8 53.16 Cm
• Pathway: Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem
• Function: calcium ion binding