Recombinant Human FOS, GST-tagged

• Cat.No.: FOS-26602TH
• Product Overview: Recombinant full-length human FOS was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~78 kDa
• Purity: >90%
• Applications: Kinase Assay; Western Blot
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ul

Gene Information

• Gene Name: FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]
• Official Symbol: FOS
• Synonyms: FOS; p55; AP-1; C-FOS; FBJ murine osteosarcoma viral oncogene homolog; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
• Gene ID: 2353
• mRNA Refseq: NM_005252
• Protein Refseq: NP_005243
• MIM: 164810
• UniProt ID: P01100
• Chromosome Location: 14q24.3
• Pathway: ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors
• Function: R-SMAD binding; double-stranded DNA binding; sequence-specific DNA binding