Recombinant Human Colony Stimulating Factor 1 Receptor

• Cat.No.: CSF1R-1666H

Specification

• Cat. No.: CSF1R-1666H
• Description: Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. It also triggers growth and development of mononuclear phagocytes and placental trophoblasts. M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.
• Source: Mammalian cells
• Molecular Weight: The predicted molecular weight of Recombinant Human M-CSF R is 81 kDa. However, as a result of glycosylation, the actual molecular weight of the monomer as observed by migration on SDS Page is 150 kDa.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: CSF1R colony stimulating factor 1 receptor [ Homo sapiens ]
• Synonyms: CSF1R; colony stimulating factor 1 receptor; CSFR; FIM2; C-FMS; CD115; CD115 antigen; FMS proto-oncogene; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; Macrophage colony-stimulating factor 1 receptor; CSF-1-R; EC 2.7.10.1; c-fms; soluble CSF1R variant 1
• Gene ID: 1436
• mRNA Refseq: NM_005211
• Protein Refseq: NP_005202
• MIM: 164770
• UniProt ID: P07333
• Chromosome Location: 5q32
• Pathway: Cytokine-cytokine receptor interaction; Endocytosis; Hematopoietic cell lineage; Pathways in cancer
• Function: ATP binding; cytokine binding; macrophage colony stimulating factor receptor activity; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity