Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His
Cat.No. : | CTLA4-1598H |
Product Overview : | Recombinant human CTLA-4 encoding amino acid residue 37-161 of the extracellular domain was fused to the Fc region of human IgG1 with six his residues added at the carboxy-terminus, cloned into a suitable expression vector and was expressed inSf 21 cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CTLA4-1598H |
Description : | CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. |
Molecular Weight : | The predicted molecular weight of Recombinant Human CTLA-4 is Mr 40 kDa. |
Source : | Sf 21 Insect Cells. |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human CTLA-4 was determined by its ability to inhibit IL-2 production by Jurkat cells stimulated with Raji cells or 1 μg/ml rhB7-1/Fc in the presence of PHA. The expected ED50 is typically 2 - 4 μg/ml with Raji cells or 0.1 - 0.4 μg/ml with rhB7-H1/Fc. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; CD28; CD152; CD152; CELIAC3; CTLA-4; celiac disease 3; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; ICOS; GSE; IDDM12; IDDM12; CTLA-4; OTTHUMP00000163781 |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
MIM : | 123890 |
UniProt ID : | P16410 |
Chromosome Location : | 2q33 |
Pathway : | Autoimmune thyroid disease ; Cell adhesion molecules (CAMs); T cell receptor signaling pathway |
Function : | Protein binding |
Products Types
◆ Recombinant Protein | ||
Ctla4-3307M | Active Recombinant Mouse Ctla4 protein(Met1-Phe162), His-tagged | +Inquiry |
CTLA4-3229H | Recombinant Human CTLA4 protein(Met1-Phe162), rFc-tagged | +Inquiry |
CTLA4-109C | Active Recombinant Cynomolgus/Rhesus CTLA4 protein(Met1-Asp161), His-tagged | +Inquiry |
CTLA4-656R | Recombinant Rabbit CTLA4 Protein, Fc-tagged | +Inquiry |
Ctla4-652H | Recombinant Human Ctla4 Protein, Strep-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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