Recombinant Human FYN

• Cat.No.: FYN-28958TH
• Product Overview: Recombinant full length Fyn protein with an N-terminal tag, expressed by baculovirus in Sf9 insect cells. MW ~85kDa.

Specification

• Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
• Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
• Biological activity: Specific activity: 166nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.

Gene Information

• Gene Name: FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ]
• Official Symbol: FYN
• Synonyms: FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN
• Gene ID: 2534
• mRNA Refseq: NM_002037
• Protein Refseq: NP_002028
• MIM: 137025
• Uniprot ID: P06241
• Chromosome Location: 6q21
• Pathway: Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem
• Function: ATP binding; ephrin receptor binding; glycoprotein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity