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Recombinant Human Ectodysplasin A2 Receptor, Fc Chimera

Cat.No. : EDA2R-1701H
Product Overview : Recombinant Human XEDAR containing the signal peptide from human CD33 joined with the extracellular domain of human XEDAR was fused to the Fc region of human IgG1 via a linker peptide, inserted into a suitable mammalian expression vector and expressed inNSO cells.
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Cat. No. : EDA2R-1701H
Description : XEDAR (X-linked Ectodysplasin A2 Receptor) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and induces apoptosis. XEDAR is a receptor for Ectodysplasin-A2 (EDA-A2) which may be a promising agent for the gene therapy of osteosarcoma.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human XEDAR is Mr 41.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 61 kDa.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Biological Activity : The biological activity of Human XEDAR was determined by its ability to bind rhEDA-A2/His. Immobilized rhXEDAR/Fc at 1 μg/mL (100 μL/well) can bind rhEDA-A2/His with a linear range of 0.045 - 5 ng/mL in a functional ELISA.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : EDA2R ectodysplasin A2 receptor [ Homo sapiens ]
Synonyms : ectodysplasin A2 receptor; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; EDA2R; X-linked ectodysplasin receptor; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor; tumor necrosis factor receptor superfamily member XEDAR; OTTHUMP00000023448; ectodysplasin A2 receptor
Gene ID : 60401
mRNA Refseq : NM_021783
Protein Refseq : NP_068555
MIM : 300276
UniProt ID : Q9HAV5
Chromosome Location : Xq12
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity; tumor necrosis factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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