Recombinant Human GGPS1, His-tagged

• Cat.No.: GGPS1-29020TH
• Product Overview: Recombinant full length Human GGPS1 (amino acids 1-300) with N terminal His tag; 320 amino acids with tag; Predicted MWt 37 kDa.

Specification

• Description: This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
• Protein length: 300 amino acids
• Conjugation: HIS
• Molecular Weight: 37.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Abundantly expressed in testis. Found in other tissues to a lower extent.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMEKTQ ETVQRILLEPYKYLLQLPGKQVRTK LSQAFNHWLKVPEDKLQIIIEVTEM LHNASLLIDDIEDNSKLRRGFPVAH SIYGIPSVINSANYVYFLGLEKVLT LDHPDAVKLFTRQLLELHQGQGLDI YWRDNYTCPTEEEYKAMVLQKTGGL FGLAVGLMQLFSDYKEDLKPLLNTL GLFFQIRDDYANLHSKEYSENKSFC EDLTEGKFSFPTIHAIWSRPESTQV QNILRQRTENIDIKKYCVHYLEDVG SFEYTRNTLKELEAKAYKQIDARGG NPELVALVKHLSKMFKEENE
• Sequence Similarities: Belongs to the FPP/GGPP synthase family.

Gene Information

• Gene Name: GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ]
• Official Symbol: GGPS1
• Synonyms: GGPS1; geranylgeranyl diphosphate synthase 1; geranylgeranyl pyrophosphate synthase; GGPPS1
• Gene ID: 9453
• mRNA Refseq: NM_001037277
• Protein Refseq: NP_001032354
• MIM: 606982
• Uniprot ID: O95749
• Chromosome Location: 1q43
• Pathway: Cholesterol biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Terpenoid backbone biosynthesis, organism-specific biosystem; Terpenoid backbone biosynthesis, conserved biosystem
• Function: dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity