| Description : |
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Protein length : |
160 amino acids |
| Molecular Weight : |
18.400kDa |
| Source : |
E. coli |
| Tissue specificity : |
Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, pu |
| Form : |
Liquid |
| Purity : |
by SDS-PAGE |
| Storage buffer : |
Constituent:0.3% Acetic acid |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids : |
MKKKGSQGAIPPPDKAQHNDSEQTQ SPQQPGSRNRGRGQGRGTAMPGEEV LESSQEALHVTERKYLKRDWCKTQP LKQTIHEEGCNSRTIINRFCYGQCN SFYIPRHIRKEEGSFQSCSFCKPKK FTTMMVTLNCPELQPPTKKKRVTRV KQCRCISIDLD |
| Sequence Similarities : |
Belongs to the DAN family.Contains 1 CTCK (C-terminal cystine knot-like) domain. |
