Recombinant Human Erythropoietin Receptor
Cat.No. : | EPOR-1614H |
- Specification
- Gene Information
- Related Products
Cat. No. : | EPOR-1614H |
Description : | The erythropoietin receptor is a transmembrane protein belonging to the member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. EPO-R transmits signals important for both proliferation and differentiation along the erythroid lineage. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human Epo R is 51.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is 55-60 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Storage : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | EPOR erythropoietin receptor [ Homo sapiens ] |
Synonyms : | EPOR; MGC138358; EPOR; erythropoietin receptor |
Gene ID : | 2057 |
mRNA Refseq : | NM_000121 |
Protein Refseq : | NP_000112 |
MIM : | 133171 |
UniProt ID : | P19235 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | erythropoietin receptor binding IEA ;hormone activity IEA ;protein binding |
Products Types
◆ Recombinant Protein | ||
Epo-01R | Active Recombinant Rat Epo protein, His-tagged | +Inquiry |
EPO-2521H | Recombinant Human EPO protein(28-193 aa), N-MBP-His-tagged | +Inquiry |
Epo-523R | Recombinant Rat Epo Protein(Pro28~Arg192), His-tagged | +Inquiry |
EPO-3423H | Recombinant Human EPO Protein, GST-tagged | +Inquiry |
EPO-1203P | Recombinant Pig EPO Protein, His-tagged | +Inquiry |
◆ Lysates | ||
EPO-592RCL | Recombinant Rat EPO cell lysate | +Inquiry |
EPO-1450MCL | Recombinant Mouse EPO cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0327 | Eosinophil Peroxidase Fluorometric Detection Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Reviews
Q&As (6)
Ask a questionEPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.
By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.
EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.
The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.
This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.
In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.
Customer Reviews (3)
Write a reviewStability is truly remarkable, can maintain its activity even under extreme conditions.
Can catalyze reactions even under extreme conditions.
This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.
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