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Recombinant Human HDAC1

Cat.No. : HDAC1-27260TH
Product Overview : Recombinant full length Human HDAC1 expressed in a Baculovirus infected Sf9 cell expression system with a C-terminal proprietary tag, 88kDa.
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  • Gene Information
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Description : Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Protein length : 482 amino acids
Molecular Weight : 88.000kDa inclusive of tags
Source : Baculovirus
Tissue specificity : Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Biological activity : The Specific activity of HDAC1-27260TH was determined to be 8900 RLU/min/ng.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the histone deacetylase family. HD type 1 subfamily.
Gene Name : HDAC1 histone deacetylase 1 [ Homo sapiens ]
Official Symbol : HDAC1
Synonyms : HDAC1; histone deacetylase 1; RPD3L1; GON 10; HD1;
Gene ID : 3065
mRNA Refseq : NM_004964
Protein Refseq : NP_004955
MIM : 601241
Uniprot ID : Q13547
Chromosome Location : 1p34
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); RNA polymerase II transcription corepressor activity; activating trans;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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