Recombinant Human HDAC4, His-tagged

• Cat.No.: HDAC4-28266TH
• Product Overview: Recombinant fragment, corresponding to amino acids 556-1084 of Human HDAC4 with a N terminal His tag; MWt 85 kDa:

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:reconstitution with 125 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: VQVKQEPIESDEEEAEPPREVEPGQ RQPSEQELLFRQQAL LLEQQRIHQLRNYQASMEAAGIPVS FGGHRPLSRAQSS PASATFPVSVQEPPTKPRFTTGLVY DTLMLKHQCTCGS SSSHPEHAGRIQSIWSRLQETGLRG KCECIRGRKATLEEL QTVHSEAHTLLYGTNPLNRQKLDSK KLLGSLASVFVRL PCGGVGVDSDTIWNEVHSAGAARLA VGCVVELVFKVAT GELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLL QQRLSVSKILIVDWDVHHGNGTQQA FYSDPSVLYMSLHRY DDGNFFPGSGAPDEVGTGPGVGFNV NMAFTGGLDPPMG DAEYLAAFRTVVMPIASEFAPDVVL VSSGFDAVEGHPT PLGGYNLSARCFGYLTKQLMGLAGG RIVLALEGGHDLTAICDASEACVSA LLGNELDPLPEKVLQQRPNANAVRS MEK VMEIHSKYWRCLQRTTSTAGRSLIE AQTCENEEAETVT AMASLSVGVKPAEKRPDEEPMEEEP PL
• Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
• Official Symbol: HDAC4
• Synonyms: HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• Uniprot ID: P56524
• Chromosome Location: 2q37.3
• Pathway: Cell cycle, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity