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Recombinant Human HDAC7

Cat.No. : HDAC7-29191TH
Product Overview : Recombinant fragment of Human HDAC7 expressed in a Baculovirus infected Sf9 cell expression system with N-terminal proprietary tag, 80kDa.
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  • Gene Information
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Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 452 amino acids
Molecular Weight : 80.000kDa inclusive of tags
Source : Baculovirus
Biological activity : The Specific activity of HDAC7-29191TH was determined to be 80 RLU/min/ng.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the histone deacetylase family. HD type 2 subfamily.
Gene Name : HDAC7 histone deacetylase 7 [ Homo sapiens ]
Official Symbol : HDAC7
Synonyms : HDAC7; histone deacetylase 7; HDAC7A, histone deacetylase 7A; DKFZP586J0917;
Gene ID : 51564
mRNA Refseq : NM_001098416
Protein Refseq : NP_001091886
MIM : 606542
Uniprot ID : Q8WUI4
Chromosome Location : 12q13.1
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem;
Function : 14-3-3 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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