Recombinant Human ERBB3
Cat.No. : | ERBB3-1613H |
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- Gene Information
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Cat. No. : | ERBB3-1613H |
Description : | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), also known as ERBB3 is a member of the epidermal growth factor (EGF) receptor subfamily of receptor tyrosine kinases and is believed to be a receptor for an unknown ligand. ErbB3 has a heregulin (HRG) or neuregulin binding domain but lacks intrinsic protein tyrosine kinase activity. Therefore, it can bind to the ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of ErbB3 and/or over-expression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human ErbB3 is 96 kDa. However, the actual molecular weight as observed by migration on SDS Page is 130-140 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human ErbB3 was determined by its ability to inhibit the biological activity of human Neuregulin-1-b1 on MCF-7 cells. The expected ED50 for this effect in the presence of 10 ng/mL rhNRG-1-b1 is 1.5-6.0 mg/mL. |
Storage : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Synonyms : | ErbB-3; HER3; MDA-BF-1; MGC88033; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; EC 2.7.10.1; ErbB-3; HER3; MDA-BF-1; MGC88033; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; EC 2.7.10.1; LCCS2; Receptor tyrosine-protein kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2; Receptor tyrosine-protein kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); ERBB3 |
Gene ID : | 2065 |
mRNA Refseq : | NM_001005915 |
Protein Refseq : | NP_001005915 |
MIM : | 190151 |
UniProt ID : | P21860 |
Chromosome Location : | 12q13 |
Pathway : | Calcium signaling pathway; ErbB signaling pathway |
Function : | ATP binding ; growth factor binding; nucleotide binding ; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
ERBB3-2117H | Recombinant Human ERBB3 Protein, MYC/DDK-tagged | +Inquiry |
ERBB3-44H | Active Recombinant Human ERBB3(Ser20-Thr643), Fc-tagged | +Inquiry |
ERBB3-123E | Active Recombinant Human ERBB3 Fragment Protein (171 aa) | +Inquiry |
ERBB3-7276H | Active Recombinant Human ERBB3 protein(Pro 730-Ser 1065), His&GST-tagged | +Inquiry |
Erbb3-384M | Recombinant Mouse Erbb3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1765MCL | Recombinant Mouse ERBB3 cell lysate | +Inquiry |
ERBB3-1415RCL | Recombinant Rat ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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