Recombinant Human Fibroblast Growth Factor Receptor 4

• Cat.No.: FGFR4-493H

Specification

• Cat. No.: FGFR4-493H
• Description: Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity that is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous. FGFR4 plays essential roles in systemic lipid and glucose homeostasis. FGFR4 may be an important regulator of osteogenesis with involvement in preosteoblast proliferation and differentiation as well as osteoblast functioning during intramembranous ossification. FGFR-4 signaling and receptor turnover are important potential therapeutic targets in prostate cancer.
• Molecular Weight: The predicted molecular weight of Recombinant Human FGFR4 is Mr 65 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100-110 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ]
• Synonyms: FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; MGC20292; OTTHUMP00000161430; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; EC 2.7.10.1; FGFR-4
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• MIM: 134935
• UniProt ID: P22455
• Chromosome Location: 5q33-qter
• Pathway: Endocytosis; MAPK signaling pathway; Regulation of actin cytoskeleton
• Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity