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Recombinant Mouse FMS-like Tyrosine Kinase 3 Ligand

Cat.No. : Flt3l-188M
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Cat. No. : Flt3l-188M
Description : Fms-related tyrosine kinase 3 ligand (FLT3LG) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, such as IL-7 and IL-3, Flt-3 ligand promotes long-term expansion and differentiation of human pro-B-cells.Flt3 ligand is a cytokine capable of inducing large numbers of dendritic cells that dramatically enhances the sensitivity of antigen-specific B and T cell responses to systemic injection of a soluble protein. Through a CD40-CD40 ligand-dependent mechanism Flt-3 Ligand influences the class of antibody produced and enables productive immune responses.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Mouse Flt3-Ligand is Mr 18 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 18-32 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Publication :
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination. (2015)
Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis (2013)
Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis (2012)
Gene Name : Flt3l FMS-like tyrosine kinase 3 ligand [ Mus musculus ]
Synonyms : Flt3l; FMS-like tyrosine kinase 3 ligand; Ly72L; Flt3lg; Flt3l
Gene ID : 14256
mRNA Refseq : NM_013520
Protein Refseq : NP_038548
UniProt ID : P49772
Chromosome Location : 7 B2-C; 7 23.0 cM
Function : cytokine activity; kinase activity; protein homodimerization activity; receptor tyrosine kinase binding; receptor tyrosine kinase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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In what ways does FLT3L impact the differentiation of hematopoietic progenitor cells? 02/21/2023

FLT3L promotes the differentiation of hematopoietic progenitor cells into various blood cell lineages, contributing to the diversity of blood cell types.

Are there any side effects associated with FLT3L-based therapies? 10/07/2022

Common side effects may include flu-like symptoms, fatigue, and gastrointestinal disturbances, but the severity varies among individuals.

How does FLT3L influence dendritic cell development and function? 06/13/2022

FLT3L is a crucial factor in the development and maturation of dendritic cells, playing a role in immune response regulation.

How does FLT3L contribute to the maintenance of hematopoietic stem cells in the bone marrow? 06/30/2021

FLT3L supports the maintenance and self-renewal of hematopoietic stem cells in the bone marrow, influencing the overall balance of blood cell production.

Can FLT3L be used as a prognostic marker in leukemia patients? 05/22/2017

Yes, elevated FLT3L levels can serve as a prognostic marker, helping to predict the likelihood of relapse and overall survival in leukemia patients.

Customer Reviews (3)

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Reviews
01/23/2023

    I am confident in the manufacturer's ability to deliver outstanding technical support.

    04/04/2021

      By incorporating the FLT3L protein into my experiments, I am confident that I am utilizing a product that meets the highest standards of quality and performance.

      08/28/2018

        Its high purity and integrity provide the necessary assurance for consistent and reliable results, enabling me to achieve precise and meaningful outcomes in my research.

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