Recombinant Human HSPB8, His-tagged

• Cat.No.: HSPB8-27526TH
• Product Overview: Recombinant full length Human Hsp22 (amino acids 1-196) containing an N-terminal His tag, 216 amino acids with a predicted MWt of 23.7 kDa including tag.

Specification

• Description: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
• Protein length: 196 amino acids
• Conjugation: HIS
• Molecular Weight: 23.700kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Predominantly expressed in skeletal muscle and heart.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.58% Sodium chloride, 0.32% Tris HCl
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT
• Sequence Similarities: Belongs to the small heat shock protein (HSP20) family.

Gene Information

• Gene Name: HSPB8 heat shock 22kDa protein 8 [ Homo sapiens ]
• Official Symbol: HSPB8
• Synonyms: HSPB8; heat shock 22kDa protein 8; heat shock 27kDa protein 8; heat shock protein beta-8; E2IG1; H11; HSP22; HspB8
• Gene ID: 26353
• mRNA Refseq: NM_014365
• Protein Refseq: NP_055180
• MIM: 608014
• Uniprot ID: Q9UJY1
• Chromosome Location: 12q24.23
• Function: identical protein binding; protein binding; protein serine/threonine kinase activity