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Recombinant Human HTR2B

Cat.No. : HTR2B-26027TH
Product Overview : Recombinant fragment corresponding to amino acids 1-56 of Human 5HT2B Receptor with N terminal proprietary tag; predicted MWt 31.79 kDa inclusive of tag.
  • Specification
  • Gene Information
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Description : This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
Protein length : 56 amino acids
Molecular Weight : 31.790kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Detected in most peripheral organs. Only low expression levels were found in the brain.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MALSYRVSELQSTIPEHILQSTFVH VISSNWSGLQTESIPEEMKQIVEEQ GNKLHW
Sequence Similarities : Belongs to the G-protein coupled receptor 1 family.
Gene Name : HTR2B 5-hydroxytryptamine (serotonin) receptor 2B [ Homo sapiens ]
Official Symbol : HTR2B
Synonyms : HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT2B;
Gene ID : 3357
mRNA Refseq : NM_000867
Protein Refseq : NP_000858
MIM : 601122
Uniprot ID : P41595
Chromosome Location : 2q36.3-q37.1
Pathway : Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function : G-protein alpha-subunit binding; G-protein coupled receptor activity; Ras GTPase activator activity; calcium channel activity; drug binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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