Recombinant Human Intercellular Adhesion Molecule 1, Fc Chimera
Cat.No. : | ICAM1-1625H |
Product Overview : | Recombinant Human ICAM-1 was expressed inNSO cells.The extracellular domain of human ICAM-1 (amino acid residues 1 - 480) was fused to the carboxy-terminal Fc region of human IgG1 via a polypeptide linker. |
- Specification
- Gene Information
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Cat. No. : | ICAM1-1625H |
Description : | Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human ICAM-1 is Mr 70 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110-125 kDa. |
Formulation : | The recombinant protein was 0.2 μm filtered and lyophilized from PBS. |
Biological Activity : | The biological activity of Human ICAM-1 was determined by the ability of the immobilized protein to support the adhesion of HSB2 cells, a human peripheral blood acute lymphoblastic leukemia cell line. When 5 x 104 cells/well are added to recombinant human ICAM/Fc coated plates (12.5 μg/ml with 100 μl/well), approximately 60 - 70% will adhere after PMA stimulation for 1 hour at RT. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ] |
Synonyms : | ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; human rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54 antigen; cell surface glycoprotein P3.58; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
Gene ID : | 3383 |
mRNA Refseq : | NM_000201 |
Protein Refseq : | NP_000192 |
MIM : | 147840 |
UniProt ID : | P05362 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Integrin cell surface interactions; Signaling in Immune system |
Function : | integrin binding ; protein binding ; transmembrane receptor activity |
Products Types
◆ Recombinant Protein | ||
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ICAM1-292H | Recombinant Human ICAM1 Protein, Fc-tagged | +Inquiry |
ICAM1-22H | Recombinant Human ICAM1 Protein, Fc-His-tagged | +Inquiry |
ICAM1-14H | Active Recombinant Human ICAM1 Protein (28-480aa), C-hIgG-His-tagged | +Inquiry |
ICAM1-799H | Recombinant Human ICAM1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ICAM1-2655HCL | Recombinant Human ICAM1 cell lysate | +Inquiry |
ICAM1-2487MCL | Recombinant Mouse ICAM1 cell lysate | +Inquiry |
ICAM1-1970RCL | Recombinant Rat ICAM1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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