Recombinant Human IFNAR2, His-tagged

• Cat.No.: IFNAR2-27987TH
• Product Overview: Recombinant fragment, corresponding to amino acids 24-188 of Human IFNAR2 with His tag produced in the endosperm tissue of barley grain ; 166 amino acids , 21.5 kDa.

Specification

• Description: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
• Conjugation: HIS
• Tissue specificity: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
• Biological activity: Bioactivity:Bioactivity is assayed by measuring the dose dependent cytotoxicity of human IFN-alpha-2a on TF-1 in the presence of IL4. The ED50 was determined to be 0,108 ng/mg, corresponding to specific activity of 9.26x106 U/mg.IFNAR2-27987TH carries no
• Form: Lyophilised:It is recommended to reconstitute the lyophilized protein in sterile phosphate-buffered saline to a concentration of no less than 100 μg/ml. For long term storage of the reconstituted solution it is recommended to add a carrier protein (0.1% H
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS, pH 7.2
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the type II cytokine receptor family.

Gene Information

• Gene Name: IFNAR2 interferon (alpha, beta and omega) receptor 2 [ Homo sapiens ]
• Official Symbol: IFNAR2
• Synonyms: IFNAR2; interferon (alpha, beta and omega) receptor 2; IFNABR; interferon alpha/beta receptor 2
• Gene ID: 3455
• mRNA Refseq: NM_000874
• Protein Refseq: NP_000865
• MIM: 602376
• Uniprot ID: P48551
• Chromosome Location: 21q22.1
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Hepatitis C, organism-specific biosystem
• Function: protein binding; protein kinase binding; receptor activity; type I interferon binding; type I interferon receptor activity