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Recombinant Human IFNGR1, Fc-tagged

Cat.No. : IFNGR1-28503TH
Product Overview : Recombinant fragment, corresponding to the extracellular domain (amino acids 18-245) of Human IFNGR1 fused to the Fc region of Human IgG1 (aa 93-330). The chimeric protein was expressed in modified Human 293 cells.
  • Specification
  • Gene Information
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Description : This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
Conjugation : Fc
Biological activity : The ED50 of IFNGR1 (Fc Chimera) is typically 0.05-0.1 μg/ml as measured by its ability to neutralize IFN gamma mediated cytotoxicity using the HT-29 colorectal adenocarcinoma cell line.
Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
Storage : Store at +4°C.
Sequences of amino acids : Theoretical sequence: EMGTADLGPSSVPTPTNVTIESYNM NPIVYWEYQIMPQ VPVFTVEVKNYGVKNSEWIDACINI SHHYCNISDHVGD PSNSLWVRVKARVGQKESAYAKSEE FAVCRDGKIGPPK LDIRKEEKQIMIDIFHPSVFVNGDE QEVDYDPETTCYI RVYNVYVRMNGSEIQYKILTQKEDD CDEIQCQLAIPVSSLNSQYCVSAEG VLHVWGVTTEKSKEVCITIFNSSIK GGS SNTKVDKKVEPKSCDKTHTCPPCPA PELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYK CKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLTCLVK GFYPSDIAVEWESNGQPENNYKTTP PVL DSDGSFFLYSKLTVDKSRWQQGNVF SCSVMHEALHNHY TQKSLSLSPGK
Sequence Similarities : Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Gene Name : IFNGR1 interferon gamma receptor 1 [ Homo sapiens ]
Official Symbol : IFNGR1
Synonyms : IFNGR1; interferon gamma receptor 1; IFNGR; CD119;
Gene ID : 3459
mRNA Refseq : NM_000416
Protein Refseq : NP_000407
MIM : 107470
Uniprot ID : P15260
Chromosome Location : 6q23-q24
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine binding; interferon-gamma receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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