Recombinant Human IGF1R
Cat.No. : | IGF1R-29114TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 1213-1367 of Human IGF1 Receptor, |
- Specification
- Gene Information
- Related Products
Description : | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. |
Source : | E. coli |
Tissue specificity : | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 3 fibronectin type-III domains.Contains 1 protein kinase domain. |
Gene Name : | IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] |
Official Symbol : | IGF1R |
Synonyms : | IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; |
Gene ID : | 3480 |
mRNA Refseq : | NM_000875 |
Protein Refseq : | NP_000866 |
MIM : | 147370 |
Uniprot ID : | P08069 |
Chromosome Location : | 15q26.3 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; |
Products Types
◆ Recombinant Protein | ||
IGF1R-22M | Active Recombinant Mouse IGF1R Protein, His-tagged | +Inquiry |
IGF1R-0996H | Recombinant Human IGF1R Protein (S982-K1286), Tag Free | +Inquiry |
IGF1R-2037R | Recombinant Rhesus Macaque IGF1R Protein, His (Fc)-Avi-tagged | +Inquiry |
IGF1R-299H | Recombinant Human IGF1R Protein, His and Strep-tagged | +Inquiry |
IGF1R-2589H | Recombinant Human IGF1R protein(761-930 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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