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Recombinant Human IGFBP3

Cat.No. : IGFBP3-26377TH
Product Overview : Recombinant full length Human IGFBP3 expressed in modified human 293 cells; amino acids 28-291 , Predicted MWt 28.7 kDa.
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  • Gene Information
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Description : This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Tissue specificity : Expressed by most tissues. Present in plasma.
Biological activity : Activity:The ED50 of IGFBP3-26377TH is typically 0.13-0.20 μg/ml as measured by its ability to neutralize rhIGF-II mediated proliferation of the MCF7 adenocarcinoma cell line.
Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not rec
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
Storage : Store at +4°C.
Sequences of amino acids : GASSGGLGPVVRCEPCDARALAQCA PPPAVCAELVREPGC GCCLTCALSEGQPCGIYTERCGSGL RCQPSPDEARPLQ ALLDGRGLCVNASAVSRLRAYLLPA PPAPGNASESEED RSAGSVESPSVSSTHRVSDPKFHPL HSKIIIIKKGHAK DSQRYKVDYESQSTDTQNFSSESKR ETEYGPCRREMED TLNHLKFLNVLSPRGVHIPNCDKKG FYKKKQCRPSKGRKRGFCWCVDKYG QPLPGYTTKGKEDVHCYSMQSK
Sequence Similarities : Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
Gene Name : IGFBP3 insulin-like growth factor binding protein 3 [ Homo sapiens ]
Official Symbol : IGFBP3
Synonyms : IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding pr
Gene ID : 3486
mRNA Refseq : NM_000598
Protein Refseq : NP_000589
MIM : 146732
Uniprot ID : P17936
Chromosome Location : 7p13-p12
Pathway : Diabetes pathways, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem; Transcriptional misregulation in cancers, organism-specific biosystem;
Function : insulin-like growth factor I binding; insulin-like growth factor binding; metal ion binding; protein binding; protein tyrosine phosphatase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic factors that influence IGFBP3 protein levels? 08/11/2022

Yes, genetic variations can affect IGFBP3 expression, potentially leading to differences in protein levels among individuals.

How does IGFBP3 protein influence bone health? 11/24/2021

IGFBP3 is involved in bone metabolism and is associated with bone mineral density. Low levels of IGFBP3 have been linked to decreased bone density and increased risk of fractures.

Are there any side effects associated with therapies targeting IGFBP3? 08/04/2021

The potential side effects of therapies targeting IGFBP3 are still being studied, and it varies depending on the specific treatment approach being used.

How do lifestyle factors such as diet and exercise influence IGFBP3 levels? 04/23/2021

Healthy lifestyle choices, including a balanced diet and regular exercise, can positively influence IGFBP3 levels, promoting overall health and reducing the risk of related diseases.

What are the implications of IGFBP3 deficiency in children's growth and development? 01/14/2021

IGFBP3 deficiency can impact children's growth and development, potentially leading to short stature and delayed puberty, as IGFBP3 is a key regulator of growth hormone actions.

Customer Reviews (3)

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05/04/2020

    A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.

    01/20/2019

      A reliable manufacturer should be able to provide a consistently pure and high-quality IGFBP3 protein, ensuring that the samples are suitable for research purposes.

      01/02/2019

        This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.

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