Recombinant Human IL20, His-tagged

• Cat.No.: IL20-29777TH
• Product Overview: Recombinant full length mature Human IL20 with His tag produced in the endosperm tissue of barley grain ; 169 amino acids with tag, Predicted MWt 19.8 kDa.

Specification

• Description: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
• Conjugation: HIS
• Tissue specificity: Expressed at very low levels in skin, trachea, and other tissues.
• Biological activity: Bioactivity:For this bioassay, a lymphoma cell line (BW5147) stably transfected with both chains of the IL20 receptor was used. To measure IL20 activity, these cells were transiently tranfected with a luciferase reporter construct which specifically respo
• Form: Lyophilised:Reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS, pH 7.2
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequence Similarities: Belongs to the IL-10 family.

Gene Information

• Gene Name: IL20 interleukin 20 [ Homo sapiens ]
• Official Symbol: IL20
• Synonyms: IL20; interleukin 20; interleukin-20; IL 20; IL10D; ZCYTO10
• Gene ID: 50604
• mRNA Refseq: NM_018724
• Protein Refseq: NP_061194
• MIM: 605619
• Uniprot ID: Q9NYY1
• Chromosome Location: 1q32
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine activity; interleukin-20 receptor binding; receptor binding