Recombinant Human IL2RB, Fc-tagged
Cat.No. : | IL2RB-29776TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 27-237 of Human IL2 Receptor beta fused to the Fc region of human IgG1 expressed in modified human 293 cells. |
- Specification
- Gene Information
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Description : | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. |
Conjugation : | Fc |
Biological activity : | IL2RB-29776TH bound to protein A sepharose beads is able to pull down its ligand, IL2. |
Form : | Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
Storage : | Store at +4°C. |
Sequences of amino acids : | Theoretical Sequence:AVNGTSQFTCFYNSRANISCVWSQD GALQ DTSCQVHAWPDRRRWNQTCELLPVS QASWACNLILGAP DSQKLTTVDIVTLRVLCREGVRWRV MAIQDFKPFENLR LMAPISLQVVHVETHRCNISWEISQ ASHYFERHLEFEARTLSPGHTWEEA PLLTLKQKQEWICLETLTPDTQYEF QVR VKPLQGEFTTWSPWSQPLAFRTKPA ALGIPKVDKKVEP KSCDKTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKE YKCKVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK |
Gene Name : | IL2RB interleukin 2 receptor, beta [ Homo sapiens ] |
Official Symbol : | IL2RB |
Synonyms : | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; |
Gene ID : | 3560 |
mRNA Refseq : | NM_000878 |
Protein Refseq : | NP_000869 |
MIM : | 146710 |
Uniprot ID : | P14784 |
Chromosome Location : | 22q13 |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function : | interleukin-2 binding; interleukin-2 receptor activity; contributes_to interleukin-2 receptor activity; receptor activity; |
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IL2RB-2699R | Recombinant Rat IL2RB Protein, His (Fc)-Avi-tagged | +Inquiry |
IL2RB-783H | Active Recombinant Human IL2RB protein(Met1-Asp239) | +Inquiry |
◆ Lysates | ||
IL2RB-744MCL | Recombinant Mouse IL2RB cell lysate | +Inquiry |
IL2RB-741CCL | Recombinant Canine IL2RB cell lysate | +Inquiry |
IL2RB-2906HCL | Recombinant Human IL2RB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.
There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.
This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.
IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).
IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.
IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.
Customer Reviews (3)
Write a reviewImmunogenicity is very weak and does not cause an immune response.
Detection method is very sensitive and can detect trace amounts of protein.
Preparation process is very simple and can be easily prepared.
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